Effect of alpha-tocopherol on in vitro and in vivo metabolism of low-density lipoproteins in haemodialysis patients

Nephrol Dial Transplant. 1995;10 Suppl 3:1-3. doi: 10.1093/ndt/10.supp3.1.

Abstract

It has been reported that some modified low-density lipoproteins (LDLs) such as glycated LDL and malondialdehyde-rich LDL (MDA-LDL) probably exist in the circulation. The present study was undertaken to investigate the in vitro and in vivo metabolism of MDA-LDL occurring in chronic haemodialysis patients and the effects of alpha-tocopherol on these abnormalities. MDA-LDL from haemodialysis patients was degraded more rapidly by human monocyte-derived macrophages and disappeared more slowly from the circulation when compared with LDL from healthy controls. Treatment with alpha-tocopherol at doses of 600 mg/day for 2 weeks resulted in improvement of these metabolic abnormalities depending upon the degree of return to normal MDA concentrations in LDL.

Publication types

  • Comparative Study

MeSH terms

  • Humans
  • Lipoproteins, LDL / drug effects
  • Lipoproteins, LDL / metabolism*
  • Macrophages / drug effects
  • Macrophages / metabolism*
  • Male
  • Malondialdehyde / metabolism*
  • Renal Dialysis*
  • Vitamin E / pharmacology*

Substances

  • Lipoproteins, LDL
  • Vitamin E
  • Malondialdehyde