T lymphocyte receptor deficiencies

Curr Opin Immunol. 1995 Aug;7(4):441-7. doi: 10.1016/0952-7915(95)80086-7.


Signalling through the TCR is mediated by the cytoplasmic tails of the CD3 complex. Deficiencies in the expression of different CD3 components have lead to dramatic, yet dissimilar, effects on T-cell development and to selective deficits in peripheral T-cell subsets. Recent studies of human patients and animal models with CD3 deficiencies are providing insights into the redundant and unique roles of these molecules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Immunologic Deficiency Syndromes / genetics*
  • Immunologic Deficiency Syndromes / immunology
  • Molecular Sequence Data
  • Receptor-CD3 Complex, Antigen, T-Cell / biosynthesis
  • Receptor-CD3 Complex, Antigen, T-Cell / deficiency*
  • Receptor-CD3 Complex, Antigen, T-Cell / genetics


  • Receptor-CD3 Complex, Antigen, T-Cell