T lymphocyte receptor deficiencies

Curr Opin Immunol. 1995 Aug;7(4):441-7. doi: 10.1016/0952-7915(95)80086-7.

Abstract

Signalling through the TCR is mediated by the cytoplasmic tails of the CD3 complex. Deficiencies in the expression of different CD3 components have lead to dramatic, yet dissimilar, effects on T-cell development and to selective deficits in peripheral T-cell subsets. Recent studies of human patients and animal models with CD3 deficiencies are providing insights into the redundant and unique roles of these molecules.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Immunologic Deficiency Syndromes / genetics*
  • Immunologic Deficiency Syndromes / immunology
  • Molecular Sequence Data
  • Receptor-CD3 Complex, Antigen, T-Cell / biosynthesis
  • Receptor-CD3 Complex, Antigen, T-Cell / deficiency*
  • Receptor-CD3 Complex, Antigen, T-Cell / genetics

Substances

  • Receptor-CD3 Complex, Antigen, T-Cell