Entry of microbes into the host: using M cells to break the mucosal barrier

Curr Opin Immunol. 1995 Aug;7(4):474-8. doi: 10.1016/0952-7915(95)80091-3.


Enteric microbial pathogens interact with the gut epithelium to establish infection. Recently, it has become clear that many microorganisms that colonize or traverse the intestinal mucosa do so via the specialized M cells. Recent work has shown that Shigella flexneri and Salmonella typhimurium specifically target M cells to initiate infection of the host.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Carbohydrate Sequence
  • Humans
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / microbiology*
  • Molecular Sequence Data
  • Peyer's Patches / immunology*
  • Peyer's Patches / microbiology*