Induction of Th2 responses in infectious diseases

Curr Opin Immunol. 1995 Aug;7(4):497-504. doi: 10.1016/0952-7915(95)80094-8.

Abstract

Recent work on T-helper (Th) cell subset maturation has focused on defining the cellular source of early IL-4, which promotes precursor (naive) CD4+ Th cells to differentiate into Th type 2 (Th2) cells, and also on the roles of counter-regulatory cytokines, costimulatory signals, and antigen in the induction of Th2 responses. Results suggest that not all Th2 cells are equivalent in their ontogeny.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / immunology
  • Immunity, Cellular
  • Infections / immunology*
  • Th2 Cells / immunology*