Aquaporin water channels: unanswered questions and unresolved controversies

Curr Opin Cell Biol. 1995 Aug;7(4):472-83. doi: 10.1016/0955-0674(95)80003-4.


The long-standing biophysical question of how water crosses plasma membranes has been answered by the recent discovery of the aquaporins. Identification of this large family of membrane water-transport proteins has generated new questions about the physiological functions, tissue distributions, and regulatory mechanisms of individual aquaporins. The fast pace of developments in this field has also resulted in major discrepancies in published reports which warrant resolution.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biophysical Phenomena
  • Biophysics
  • Body Water / metabolism*
  • Carrier Proteins / metabolism*
  • Cell Membrane Permeability / physiology*
  • Humans
  • Ion Channels*
  • Membrane Proteins / metabolism*
  • Tissue Distribution


  • Carrier Proteins
  • Ion Channels
  • Membrane Proteins