Chloride channels of intracellular organelles

Curr Opin Cell Biol. 1995 Aug;7(4):504-8. doi: 10.1016/0955-0674(95)80006-9.


Chloride channels are present in a variety of intracellular organelles (Golgi, endosomes, endoplasmic reticulum, and sarcoplasmic reticulum) where they serve largely to shunt the membrane potential created by other ion-translocating processes. Electrophysiological studies have shown that the Cl- channels of the endoplasmic and sarcoplasmic reticula facilitate the efflux of Ca2+. In the Golgi and some endosomes, the open Cl- channels (probably the cystic fibrosis transmembrane conductance regulator) favor accumulation of H+.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Chloride Channels / physiology*
  • Endoplasmic Reticulum, Rough / metabolism
  • Endosomes / metabolism
  • Golgi Apparatus / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Organelles / metabolism*
  • Sarcoplasmic Reticulum / metabolism


  • Chloride Channels
  • Calcium