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Review
, 7 (4), 523-9

Quality Control in the Secretory Pathway

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Review

Quality Control in the Secretory Pathway

C Hammond et al. Curr Opin Cell Biol.

Abstract

Whereas newly synthesized proteins that have acquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called 'quality control', have been illuminated by recent studies.

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