Quality control in the secretory pathway

Curr Opin Cell Biol. 1995 Aug;7(4):523-9. doi: 10.1016/0955-0674(95)80009-3.


Whereas newly synthesized proteins that have acquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called 'quality control', have been illuminated by recent studies.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Endoplasmic Reticulum / metabolism
  • Glycosylation
  • Humans
  • Membrane Proteins / metabolism
  • Molecular Chaperones / metabolism
  • Protein Folding
  • Proteins / metabolism*
  • Quality Control


  • Membrane Proteins
  • Molecular Chaperones
  • Proteins