The emergence of clathrin-independent pinocytic pathways

Curr Opin Cell Biol. 1995 Aug;7(4):573-80. doi: 10.1016/0955-0674(95)80015-8.


Receptor-mediated endocytosis via clathrin-coated vesicles is by far the best characterized example of pinocytosis. It has been suggested that clathrin-coated vesicles mediate all pinocytosis in mammalian cells. This is still a matter of debate, however, and recent results provide strong evidence for 'clathrin-independent' pinocytic pathways. The selective regulation of these alternate endocytic pathways and the identification of receptors targeted to them provide new tools for the functional and mechanistic characterization of clathrin-independent pinocytosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Carbohydrate Sequence
  • Clathrin / physiology*
  • Coated Vesicles / physiology
  • Dynamins
  • GTP Phosphohydrolases / physiology
  • Humans
  • Molecular Sequence Data
  • Pinocytosis / physiology
  • Up-Regulation


  • Clathrin
  • GTP Phosphohydrolases
  • Dynamins