Pharmacokinetics of tamoxifen in premenopausal and postmenopausal women with breast cancer

J Steroid Biochem Mol Biol. 1995 Nov;55(2):229-31. doi: 10.1016/0960-0760(95)00169-z.

Abstract

We measured the serum levels of tamoxifen and 5 of its metabolites in serum from 7 premenopausal and 9 postmenopausal women during the first 56 days of treatment. The serum levels of N-desdimethyltamoxifen were higher in postmenopausal women compared to premenopausal women (P < 0.02). A similar trend was observed for N-desmethyltamoxifen (P = 0.06).

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents, Hormonal / blood
  • Antineoplastic Agents, Hormonal / pharmacokinetics*
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Biotransformation
  • Breast Neoplasms / blood
  • Breast Neoplasms / drug therapy*
  • Female
  • Humans
  • Middle Aged
  • Postmenopause*
  • Premenopause*
  • Tamoxifen / blood
  • Tamoxifen / pharmacokinetics*
  • Tamoxifen / therapeutic use
  • Time Factors

Substances

  • Antineoplastic Agents, Hormonal
  • Tamoxifen