The Trypanosomatid Rieske Iron-Sulfur Proteins Have a Cleaved Presequence That May Direct Mitochondrial Import

Biochim Biophys Acta. 1995 Nov 30;1269(3):201-4. doi: 10.1016/0167-4889(95)00154-6.

Abstract

We have cloned the gene that encodes subunit 4 of the T. brucei cytochrome-c reductase complex and a fragment of the C. fasciculata subunit 4 cDNA and have shown that subunit 4 is the Rieske iron-sulfur protein. The cleaved presequences of the trypanosomatid iron-sulfur proteins resemble conventional mitochondrial targeting presequences but are smaller than other eukaryotic iron-sulfur protein signal peptides.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Biological Transport
  • Cell Compartmentation
  • Crithidia fasciculata / metabolism
  • DNA Primers / chemistry
  • Electron Transport Complex III*
  • Iron-Sulfur Proteins / chemistry
  • Iron-Sulfur Proteins / metabolism*
  • Mitochondria / metabolism*
  • Molecular Sequence Data
  • NADH Dehydrogenase / chemistry
  • NADH Dehydrogenase / metabolism*
  • Protein Precursors / metabolism
  • Protein Processing, Post-Translational
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Trypanosoma brucei brucei / metabolism

Substances

  • DNA Primers
  • Iron-Sulfur Proteins
  • Protein Precursors
  • Rieske iron-sulfur protein
  • NADH Dehydrogenase
  • Electron Transport Complex III

Associated data

  • GENBANK/U28865
  • GENBANK/U28866