A light and electron microscopic study of calbindin D-28k immunoreactive double bouquet cells in the human temporal cortex

Brain Res. 1995 Aug 28;690(1):133-40. doi: 10.1016/0006-8993(95)00641-3.


Correlative light and electron microscopic methods were used to examine the morphology, distribution and synaptic connections of double bouquet cells immunoreactive for the calcium-binding protein calbindin D-28k in the human temporal neocortex. Double bouquet cells form symmetric synapses with small dendritic shafts and dendritic spines. The distribution and proportion of synapses found in the present work are very similar to those found in previous studies on the synaptic connectivity of double bouquet cells in the monkey cerebral cortex. Thus, double bouquet cells are probably involved in similar synaptic circuits in monkeys and humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Calbindins
  • Dendrites / ultrastructure
  • Epilepsy, Temporal Lobe / metabolism*
  • Epilepsy, Temporal Lobe / pathology
  • Humans
  • Immunoenzyme Techniques
  • Interneurons / chemistry*
  • Interneurons / pathology
  • Microscopy, Immunoelectron
  • Nerve Tissue Proteins / analysis*
  • S100 Calcium Binding Protein G / analysis*
  • Synapses / ultrastructure
  • Temporal Lobe / chemistry*
  • Temporal Lobe / pathology


  • Calbindins
  • Nerve Tissue Proteins
  • S100 Calcium Binding Protein G