Enriched HLA-DQ3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis

Clin Diagn Lab Immunol. 1994 May;1(3):357-60. doi: 10.1128/cdli.1.3.357-360.1994.


Respiratory papillomas, caused by human papillomaviruses, are benign tumors that recur following removal. We evaluated immune function and major histocompatibility complex (MHC) phenotype and expression in these patients. MHC-independent immune function appeared normal. The frequency of peripheral blood MHC class II phenotypes was highly enriched for DQ3 and DR11, one split of DR5. Class I MHC antigen expression on papilloma tissue was markedly reduced. Together, these phenomena may facilitate papillomavirus evasion of the cellular immune response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Child
  • Child, Preschool
  • Disease Susceptibility / immunology
  • Female
  • HLA-DQ Antigens / analysis*
  • Histocompatibility Antigens Class I / analysis*
  • Humans
  • Immunophenotyping
  • Male
  • Neoplasm Recurrence, Local
  • Papilloma / immunology*
  • Respiratory Tract Neoplasms / immunology*
  • Retrospective Studies


  • HLA-DQ Antigens
  • HLA-DQ3 antigen
  • Histocompatibility Antigens Class I