Expression of immunoreactive human hepatocyte growth factor in human esophageal squamous cell carcinomas

Cancer Lett. 1995 Nov 6;97(2):145-8. doi: 10.1016/0304-3835(95)03967-2.


Hepatocyte growth factor (HGF) is a potent mitogen for epithelial cells that promotes cell motility and invasiveness. In this study, we report that the human esophageal squamous cell carcinoma (SCC) shows a significant elevation of HGF concentration (600 +/- 416 ng/100 mg protein), compared to normal mucosa (80 +/- 183 ng/100 mg protein) (P < 0.01). An association could be established between levels of HGF and decreasing differentiation of 37 SCCs. The 2-year crude survival rates were 51.1% and 68.4% at high and low HGF concentrations, respectively. The results indicate that HGF is significantly increased in human esophageal SCCs, especially of poorly differentiated type. HGF might thus be useful as a biological biomarker for characterization of human esophageal SCCs.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell / chemistry*
  • Carcinoma, Squamous Cell / mortality
  • Esophageal Neoplasms / chemistry*
  • Esophageal Neoplasms / mortality
  • Female
  • Hepatocyte Growth Factor / analysis*
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Survival Rate


  • Hepatocyte Growth Factor