Effect of prostacyclin on microvascular pressures in a patient with pulmonary veno-occlusive disease

Chest. 1995 Dec;108(6):1754-6. doi: 10.1378/chest.108.6.1754.


Continuous-infusion prostacyclin improves symptom scores and decreases mortality in patients with primary pulmonary hypertension, but use of prostacyclin in patients with pulmonary veno-occlusive disease may precipitate pulmonary edema. A patient with pulmonary veno-occlusive disease received a graduated intravenous infusion of prostacyclin and pulmonary capillary pressures were calculated during prostacyclin dose ranging. Calculated capillary pressure increased with low-dose prostacyclin (< or = 6 ng/kg/min) but decreased with higher doses. These data suggest that the post-capillary pulmonary venules in our patient had reversible vasomotor tone, but required a higher dose of prostacyclin to vasodilate than did the precapillary arterioles.

Publication types

  • Case Reports

MeSH terms

  • Blood Pressure / drug effects*
  • Epoprostenol / administration & dosage
  • Epoprostenol / therapeutic use*
  • Female
  • Humans
  • Infusions, Intravenous
  • Microcirculation / drug effects
  • Microcirculation / physiopathology
  • Middle Aged
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Pulmonary Circulation / drug effects*
  • Pulmonary Veno-Occlusive Disease / drug therapy
  • Pulmonary Veno-Occlusive Disease / physiopathology*
  • Vasodilator Agents / therapeutic use*


  • Platelet Aggregation Inhibitors
  • Vasodilator Agents
  • Epoprostenol