Management of early invasive colorectal cancer. Risk of recurrence and clinical guidelines

Dis Colon Rectum. 1995 Dec;38(12):1286-95. doi: 10.1007/BF02049154.


Purpose: The purpose of this study was the evaluation of various factors in the formulation of guidelines for treatment of early invasive colorectal cancer, in which malignant cells extend through the muscularis mucosa into the submucosa but do not deeply invade the muscularis propria.

Method: A total of 182 patients were followed for at least five years or until death, with early invasive cancer diagnosed between 1982 and 1989. Patients were grouped according to the level of invasion, as follows: 64 patients with slight carcinoma invasion of the muscularis mucosa (200-300 microns; sm1), 82 with intermediate invasion (sm2), and 36 with carcinoma invasion extending to the inner surface of the muscularis propria (sm3).

Result: The configuration, diameter, and histologic grade of adenocarcinoma and lymphovascular invasion were correlated with level of invasion. After endoscopic polypectomy or local resection, 4 patients showed local recurrence and 13 patients showed lymph node metastasis. None of these 17 patients had sm1 disease. The level of invasion, configuration, and location were significant risk factors for development of lymph node metastasis or local recurrence (P < 0.05), but lymphovascular invasion, histologic grade, and diameter were not risk factors.

Conclusions: Preoperative assessment of the level of invasion using this classification, in which the submucosa is divided into three depths, may decrease the incidence of unnecessary surgery for sessile polyps. Assessment according to the level of invasion is useful in the formulation of appropriate guidelines for the treatment of early invasive cancer.

MeSH terms

  • Adenocarcinoma / pathology
  • Adenocarcinoma / secondary
  • Adenocarcinoma / surgery*
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Vessels / pathology
  • Colectomy
  • Colonic Neoplasms / pathology
  • Colonic Neoplasms / surgery*
  • Colonic Polyps / pathology
  • Colonic Polyps / surgery
  • Colonoscopy
  • Female
  • Follow-Up Studies
  • Guidelines as Topic
  • Humans
  • Incidence
  • Intestinal Mucosa / blood supply
  • Intestinal Mucosa / pathology
  • Lymph Nodes / pathology
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local / pathology*
  • Rectal Neoplasms / pathology
  • Rectal Neoplasms / surgery*
  • Reoperation
  • Risk Factors
  • Survival Rate