Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A

Eur J Pharmacol. 1995 Aug 25;282(1-3):R1-2. doi: 10.1016/0014-2999(95)00447-s.


Precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4- dichloro-phenyl)-4-methyl-1H-pyrazole carboxamide.HCl). This demonstration should provide a powerful stimulus for the systematic study of dependency on the psychoactive cannabinoids.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dronabinol / adverse effects*
  • Male
  • Piperidines / pharmacology*
  • Psychotropic Drugs / adverse effects*
  • Pyrazoles / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Cannabinoid
  • Receptors, Drug / antagonists & inhibitors*
  • Rimonabant
  • Substance Withdrawal Syndrome*


  • Piperidines
  • Psychotropic Drugs
  • Pyrazoles
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Dronabinol
  • Rimonabant