Antiplatelet activity of synthetic and natural resveratrol in red wine

Int J Tissue React. 1995;17(1):1-3.


The antiaggregating effect of the phytoalexin resveratrol (3,4,5-trihydroxystilbene), alone or associated with red wine, and polyphenol have been evaluated in vitro at different concentrations on platelet-rich plasma from healthy volunteers. Resveratrol at the concentration of 3.56 micrograms/l was able to lower platelet aggregation by 50.3% +/- 1.83. Red wine containing 1.2 mg/l of natural trans-resveratrol and 3.6 milligrams of polyphenols diluted 1000-fold (final resveratrol concentration: 1.2 micrograms/l) inhibited platelet aggregation by 41.9% +/- 2.11. By adding resveratrol to the wine up to a concentration of 1.2 micrograms/l, inhibition was raised to 78.5% +/- 4.70. These results suggest that the antiaggregating activity of resveratrol is related to its concentration in wine.

MeSH terms

  • Humans
  • Platelet Aggregation Inhibitors / pharmacology*
  • Reference Values
  • Resveratrol
  • Stilbenes / pharmacology*
  • Wine / analysis*


  • Platelet Aggregation Inhibitors
  • Stilbenes
  • Resveratrol