Macrophages and microglia in HSV-1 infected mouse brain

J Neuroimmunol. 1995 Nov;62(2):201-5. doi: 10.1016/0165-5728(95)00123-8.


We have examined the macrophage and microglial cell response in mouse brains during the course of acute herpes simplex encephalitis produced by intranasal inoculation of virus. Macrophage infiltration and a microglial cell reaction were detected from 24 h after initial detection of HSV-1 antigen in brain. Macrophage infiltration was confined to focal areas of infection but the microglial cell reaction occurred in a more widespread distribution. Following disappearance of viral antigen, with resolution of the acute infection, macrophage infiltration and a focal microglial cell reaction remained for several weeks, providing a marker of sites of previous infection.

MeSH terms

  • Animals
  • Antigens, Viral / analysis
  • Brain / pathology*
  • Brain / virology
  • Encephalitis, Viral / immunology*
  • Encephalitis, Viral / pathology
  • Herpes Simplex / immunology*
  • Herpes Simplex / pathology
  • Herpesvirus 1, Human / immunology
  • Macrophages / immunology*
  • Macrophages / pathology
  • Mice
  • Mice, Inbred BALB C
  • Microglia / immunology*
  • Microglia / pathology


  • Antigens, Viral