A Mössbauer and X-ray powder diffraction study of some ferrous hematinics

J Inorg Biochem. 1995 Jun;58(4):291-6. doi: 10.1016/0162-0134(94)00062-f.

Abstract

Iron deficiency anemia is a relatively common illness that can arise from a number of different causes. Three ferrous salts are usually used in its treatment: ferrous fumarate, gluconate, and sulfate. They are administered orally and are relatively well tolerated. These hematinics have been studied by Mössbauer spectroscopy and X-ray powder diffraction, and can easily be distinguished by both techniques. It was found that the two ferrous sulfates studied (Eckerd and SmithKline Beckman Co.) most closely resemble the monohydrate by comparison of the X-ray powder pattern with those of the JCPDS. Both the ferrous fumarate (Femiron) and gluconate (Spring Valley) had approximately 10% ferric iron present. To the authors' knowledge, this is the first reported Mössbauer spectrum for ferrous fumarate.

MeSH terms

  • Ferrous Compounds / chemistry*
  • Hematinics / chemistry*
  • Spectroscopy, Mossbauer*
  • X-Ray Diffraction*

Substances

  • Ferrous Compounds
  • Hematinics
  • ferrous sulfate
  • ferrous fumarate
  • ferrous gluconate