Hepatoprotective activity of carrot (Daucus carota L.) against carbon tetrachloride intoxication in mouse liver

J Ethnopharmacol. 1995 Jul 7;47(2):69-74. doi: 10.1016/0378-8741(95)01254-b.

Abstract

The effect of carrot extract on carbon tetrachloride (CCl4)-induced acute liver damage was evaluated. The increased serum enzyme levels (viz., glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, lactate dehydrogenase, alkaline phosphatase, sorbitol and glutamate dehydrogenase) by CCl4-induction were significantly lowered due to pretreatment with the extract. The extract also decreased the elevated serum bilirubin and urea content due to CCl4 administration. Increased activities of hepatic 5'-nucleotidase, acid phosphatase, acid ribonuclease and decreased levels of succinic dehydrogenase, glucose-6-phosphatase and cytochrome P-450 produced by CCl4 were reversed by the extract in a dose-responsive way. Results of this study revealed that carrot could afford a significant protective action in the alleviation of CCl4-induced hepatocellular injury.

MeSH terms

  • Alanine Transaminase / blood
  • Alkaline Phosphatase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Bilirubin / blood
  • Carbon Tetrachloride / administration & dosage
  • Carbon Tetrachloride / toxicity
  • Carbon Tetrachloride Poisoning / prevention & control*
  • Cytochrome P-450 Enzyme System / metabolism
  • Daucus carota*
  • Dose-Response Relationship, Drug
  • Glutamate Dehydrogenase / blood
  • Injections, Subcutaneous
  • L-Lactate Dehydrogenase / blood
  • Liver / drug effects*
  • Liver / enzymology
  • Liver / pathology
  • Liver Function Tests
  • Male
  • Mice
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Roots / metabolism
  • Sorbitol / blood
  • Urea / blood

Substances

  • Plant Extracts
  • Sorbitol
  • Urea
  • Cytochrome P-450 Enzyme System
  • Carbon Tetrachloride
  • L-Lactate Dehydrogenase
  • Glutamate Dehydrogenase
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase
  • Bilirubin