[Systemic fibrosis (generalized form of Ormond's disease). Report of a case which achieved complete remission with cyclophosphamide and corticosteroids]

Schweiz Med Wochenschr. 1995 Nov 4;125(44):2131-6.
[Article in German]


A 51-year-old engineer was admitted with progressive lower back pain which had started 4 months before. We found an elevated ESR and anemia. Chest X-ray showed bilateral polycyclic thickening of the pleura, and abdominal CT examination revealed a paraaortic tumorous lesion and a solid kidney tumor with a diameter of 5 cm on the left side. During the course of the disease we also observed an infiltration in the apex of the upper lobe of the left lung. Histological examination showed fibrotic tissue typical of Ormond's disease in the kidney tumor as well as in the pulmonary infiltrate. We diagnosed a systemic form of retroperitoneal fibrosis. Treatment with cyclophosphamide (combined with prednisone during the first 4 months) resulted in complete remission of the disease.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Hormonal / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cyclophosphamide / administration & dosage
  • Diagnosis, Differential
  • Humans
  • Kidney / pathology
  • Kidney Neoplasms / diagnosis
  • Lung / pathology
  • Male
  • Middle Aged
  • Prednisone / administration & dosage
  • Retroperitoneal Fibrosis / diagnostic imaging*
  • Retroperitoneal Fibrosis / drug therapy
  • Retroperitoneal Fibrosis / pathology
  • Tomography, X-Ray Computed


  • Antineoplastic Agents, Alkylating
  • Antineoplastic Agents, Hormonal
  • Cyclophosphamide
  • Prednisone