The Involvement of Kupffer Cells and Liver Endothelial Cells in the Clearance of Large Sized Soluble IgA Aggregates in Rats

Adv Exp Med Biol. 1995;371B:1053-5.

Abstract

These findings suggests that AIgA is bound both by KC and EC in normal situations. Because of the great phagocytic capacity of KC, the contribution of EC in handling AIgA in normal rats is minimal. However, when KC are defect or absent (as after Cl2MDP treatment), the handling of AIgA by EC may become of mayor importance, i.e. it will take over the phagocytic function of KC. Studies concerning a possible receptor on EC involved in binding of AIgA are in progress.

MeSH terms

  • Animals
  • Biopolymers / blood
  • Biopolymers / chemistry
  • Biopolymers / metabolism*
  • Complement System Proteins / metabolism
  • Endothelium / cytology
  • Endothelium / immunology
  • Immunoglobulin A / blood
  • Immunoglobulin A / chemistry
  • Immunoglobulin A / metabolism*
  • Kinetics
  • Kupffer Cells / immunology*
  • Liver / cytology
  • Liver / immunology*
  • Rats
  • Solubility

Substances

  • Biopolymers
  • Immunoglobulin A
  • polymeric IgA
  • Complement System Proteins