Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

Nat Genet. 1993 Jun;4(2):175-80. doi: 10.1038/ng0693-175.


The search for tumour-specific markers is one of the chief goals in cancer biology. We show that the translocation t(12;16)(q13:p11) in malignant myxoid liposarcoma can be a fusion of the CHOP dominant negative transcription factor gene with a novel gene, FUS, which can result in fusion of the FUS glycine-rich protein with the whole CHOP coding region. The data support the concept that protein fusion may commonly occur in solid tumours resulting in tumour-specific markers of potential clinical importance. The data also indicate the importance of transcription disruption in the pathogenesis of solid tumours.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • CCAAT-Enhancer-Binding Proteins*
  • Chromosomes, Human, Pair 12 / ultrastructure*
  • Chromosomes, Human, Pair 16 / ultrastructure*
  • DNA / genetics
  • DNA, Neoplasm / genetics
  • DNA-Binding Proteins / genetics*
  • Gene Expression Regulation, Neoplastic
  • Genes, Dominant
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Humans
  • Liposarcoma / genetics*
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics*
  • Nuclear Proteins / genetics*
  • Polymerase Chain Reaction
  • RNA-Binding Protein FUS
  • Ribonucleoproteins / genetics*
  • Transcription Factor CHOP
  • Transcription Factors / genetics*
  • Transcription, Genetic
  • Translocation, Genetic*


  • CCAAT-Enhancer-Binding Proteins
  • DDIT3 protein, human
  • DNA, Neoplasm
  • DNA-Binding Proteins
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Neoplasm Proteins
  • Nuclear Proteins
  • RNA-Binding Protein FUS
  • Ribonucleoproteins
  • Transcription Factors
  • Transcription Factor CHOP
  • DNA

Associated data

  • GENBANK/X71427
  • GENBANK/X71428