Structure and chromosomal localization of the gene encoding the human myelin protein zero (MPZ)

Genomics. 1993 Sep;17(3):755-8. doi: 10.1006/geno.1993.1400.


We describe the cloning, characterization, and chromosomal mapping of the human myelin protein zero (MPZ) gene. The gene is about 7 kb long and consists of six exons corresponding to the functional domains. All exon-intron junction sequences conform to the GT/AG rule. The 5'-flanking region of the gene has a TA-rich element (TATA-like box), two CAAT boxes, and a single defined transcription initiation site detected by the primer extension method. The gene for human MPZ was assigned to chromosome 1q22-q23 by spot blot hybridization of flow-sorted human chromosomes and fluorescence in situ hybridization. The localization of the MPZ gene coincides with the locus for Charcot-Marie-Tooth disease type 1B, determined by linkage analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Charcot-Marie-Tooth Disease / genetics
  • Chromosomes, Human, Pair 1*
  • DNA, Complementary / genetics
  • Exons
  • Humans
  • In Situ Hybridization, Fluorescence
  • Introns
  • Molecular Sequence Data
  • Myelin P0 Protein
  • Myelin Proteins / genetics*
  • Restriction Mapping


  • DNA, Complementary
  • Myelin P0 Protein
  • Myelin Proteins

Associated data

  • GENBANK/D14583
  • GENBANK/D14584
  • GENBANK/D14720
  • GENBANK/D90501