The TiPS/TINS lecture: the molecular biology of mammalian glutamate receptor channels

Trends Pharmacol Sci. 1993 Aug;14(8):297-303. doi: 10.1016/0165-6147(93)90047-N.

Abstract

In native brain membranes the principal excitatory neurotransmitter L-glutamate activates cation-conducting channels with distinct biophysical and pharmacological properties. Molecular cloning has revealed the existence of 16 channel subunits that can assemble in homomeric or heteromeric configurations in vitro to form receptor channels with disparate functional properties. This review describes the different channel types obtained by recombinant means and the genetic mechanisms controlling the expression of functionally important channel structures.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Chemistry
  • Cloning, Molecular
  • Humans
  • Ion Channels / drug effects
  • Ion Channels / physiology*
  • Receptors, Glutamate / drug effects
  • Receptors, Glutamate / physiology*
  • Recombinant Proteins

Substances

  • Ion Channels
  • Receptors, Glutamate
  • Recombinant Proteins