Plasmalemmal Caveolae and GPI-anchored Membrane Proteins

Curr Opin Cell Biol. 1993 Aug;5(4):647-52. doi: 10.1016/0955-0674(93)90135-d.


Caveolae are essential endocytic organelles that use glycosyl-phosphatidyl-inositol (GPI)-anchored membrane proteins to concentrate low molecular weight substances before delivery to the cell. Caveolae and GPI-anchored proteins are uniquely adapted for this task. Recent advances suggest that this endocytic pathway also has an important role in modulating the interaction of a cell with its environment. Many vital functions that occur in this organelle remain to be discovered.

Publication types

  • Review

MeSH terms

  • Animals
  • CSK Tyrosine-Protein Kinase
  • Calcium Channels / analysis
  • Cell Membrane / ultrastructure*
  • Glycosylphosphatidylinositols / chemistry*
  • Humans
  • Inositol 1,4,5-Trisphosphate
  • Inositol 1,4,5-Trisphosphate Receptors
  • Membrane Proteins / chemistry*
  • Organelles / ultrastructure*
  • Protein-Tyrosine Kinases / chemistry
  • Proto-Oncogene Proteins pp60(c-src) / chemistry
  • Receptors, Cytoplasmic and Nuclear / analysis
  • src-Family Kinases


  • Calcium Channels
  • Glycosylphosphatidylinositols
  • ITPR1 protein, human
  • Inositol 1,4,5-Trisphosphate Receptors
  • Membrane Proteins
  • Receptors, Cytoplasmic and Nuclear
  • Inositol 1,4,5-Trisphosphate
  • Protein-Tyrosine Kinases
  • CSK Tyrosine-Protein Kinase
  • Proto-Oncogene Proteins pp60(c-src)
  • src-Family Kinases
  • CSK protein, human