Correlates of ventricular ectopic activity in isolated systolic hypertension. SHEP Cooperative Research Group

Am Heart J. 1994 Jan;127(1):112-21. doi: 10.1016/0002-8703(94)90516-9.


Ventricular ectopic activity was recorded at baseline in 5.6% of the 12-lead electrocardiograms and 8.2% of the 2-minute rhythm strips of 4674 subjects with isolated systolic hypertension (systolic blood pressure 160 to 219 mm Hg, diastolic blood pressure < 90 mm Hg) participating in the Systolic Hypertension in the Elderly Program (SHEP). In this study 1.3% had 6 to 10 ventricular premature beats (VPB), and 0.7% had > 10 VPB on the 2-minute rhythm strip. Correlates of VPB presence on the 12-lead ECG were older-age male sex, presence of Q/QS pattern and higher heart rate. Participants with serum potassium < 3.5 mmol/L had a higher prevalence of VPB. Similarly, the number of VPB on the 2-minute rhythm strip was associated with male sex, increasing age, with lower serum potassium, history of palpitations, and presence of Q/QS patterns.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Cardiac Complexes, Premature / complications*
  • Cardiac Complexes, Premature / epidemiology
  • Female
  • Humans
  • Hypertension / complications*
  • Logistic Models
  • Male
  • Middle Aged
  • Prevalence
  • Risk Factors
  • Systole