New finding of Schinzel-Giedion syndrome: a case with a malignant sacrococcygeal teratoma

Am J Med Genet. 1993 Nov 1;47(6):852-6. doi: 10.1002/ajmg.1320470611.

Abstract

We report on a boy with Schinzel-Giedion syndrome (SGS) with a previously unreported manifestation, a malignant sacrococcygeal teratoma. This is the second case of SGS to have a malignancy, as one earlier case had a hepatoblastoma. We postulate that the occurrence of 2 uncommon embryonic tumors among these patients with a rare syndrome may mean that risk of malignancy may be a component of this syndrome.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple* / genetics
  • Brain / pathology
  • Coccyx
  • Developmental Disabilities / complications*
  • Developmental Disabilities / genetics
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Risk Factors
  • Sacrum
  • Syndrome
  • Teratoma / complications*
  • Teratoma / diagnosis
  • Teratoma / surgery