CD5+ B cells and the immune system

Immunol Lett. 1993 Oct;38(2):159-66. doi: 10.1016/0165-2478(93)90182-2.


The CD5+ B-cell population is prominent in early life and may play a key role in the ontogeny of the immune system. Transplantation studies in mice are in support of CD5+ B cells as a separate lineage from CD5- B cells. In both mice and men there is evidence in favour of CD5 being an activation antigen rather than a lineage marker, but the jury is still out! The frequency of CD5+ B cells appears to be under genetic influence. CD5+ B cells are receptive to many cytokines including IL-2 and IL-5 and themselves produce a number of cytokines especially IL-10. The function of the CD5 molecule on B cells is presently unknown but it might be involved in interaction with CD72 on other B cells. CD5+ B cells generally utilise minimally mutated germ-line genes and produce low avidity auto- and polyreactive antibodies (natural antibodies) generally of the IgM class.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibody Formation / physiology
  • Antigen Presentation
  • Antigens, CD / blood*
  • Autoantibodies / biosynthesis
  • B-Lymphocyte Subsets / physiology*
  • Biomarkers
  • CD5 Antigens
  • Genes, Immunoglobulin
  • Humans
  • Immune Tolerance
  • Immunoglobulin Idiotypes / immunology
  • Self Tolerance


  • Antigens, CD
  • Autoantibodies
  • Biomarkers
  • CD5 Antigens
  • Immunoglobulin Idiotypes