Chemosensitivity of C-cells in bullfrog dorsal root ganglia to substance P and adenosine 5'-triphosphate

Neurosci Lett. 1993 Dec 12;163(2):169-72. doi: 10.1016/0304-3940(93)90374-t.


Dissociated bullfrog dorsal root ganglion cells were voltage clamped in the whole-cell configuration. In small C-cells having 20 microns as averaged diameter, substance-P (0.1-1 microM) inhibited an M-type potassium current while ATP (1-10 microM) activated a sodium-potassium current. In large A-cells (approximately 65 microns in diameter) in which ATP has been shown to inhibit M-current, substance P (0.1-1 microM) also inhibited this potassium current without activating the sodium-potassium current. Results provided evidence for the distinction between A- and C-cells in terms of their chemosensitivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / pharmacology*
  • Animals
  • Calcium Channels / drug effects
  • Calcium Channels / physiology
  • Electric Conductivity
  • Evoked Potentials / drug effects
  • Ganglia, Spinal / cytology
  • Ganglia, Spinal / drug effects
  • Ganglia, Spinal / physiology*
  • In Vitro Techniques
  • Neurons / cytology
  • Neurons / drug effects
  • Neurons / physiology*
  • Rana catesbeiana
  • Substance P / pharmacology*


  • Calcium Channels
  • Substance P
  • Adenosine Triphosphate