Comparison between the effects of VIP and the novel peptide PACAP on the exocrine pancreatic secretion of the rat

Pancreas. 1994 Jan;9(1):123-8. doi: 10.1097/00006676-199401000-00018.


The effect of intravenous infusion of pituitary adenylate cyclase-activating peptide (PACAP) 27, a novel regulatory peptide that shows a close structural and chemical similarity to vasoactive intestinal peptide (VIP), on the rat exocrine pancreatic secretion was studied. PACAP and VIP stimulated the flow rate of exocrine pancreatic secretion (p < 0.05). However, protein output and amylase secretion were mainly stimulated by PACAP. Intravenous infusion of VIP increased the plasma levels of secretin (p < 0.05). On the other hand, PACAP released neither secretin nor VIP. Our results show: (a) both PACAP and VIP stimulate exocrine pancreatic secretion, (b) PACAP stimulation of pancreatic amylase and protein secretion is greater than that induced by VIP, and (c) PACAP probably exerts a direct effect on exocrine pancreas whereas some of the actions of VIP might be mediated by secretin.

Publication types

  • Comparative Study

MeSH terms

  • Amylases / metabolism
  • Animals
  • Male
  • Neuropeptides / pharmacology*
  • Neurotransmitter Agents / pharmacology*
  • Pancreas / drug effects
  • Pancreas / metabolism*
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Rats
  • Rats, Wistar
  • Secretin / metabolism
  • Vasoactive Intestinal Peptide / metabolism
  • Vasoactive Intestinal Peptide / pharmacology*


  • Adcyap1 protein, rat
  • Neuropeptides
  • Neurotransmitter Agents
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Secretin
  • Vasoactive Intestinal Peptide
  • Amylases