Prostate-specific antigen decline after casodex withdrawal: evidence for an antiandrogen withdrawal syndrome

Urology. 1994 Mar;43(3):408-10. doi: 10.1016/0090-4295(94)90092-2.


Objective: To evaluate the relationship between antiandrogen withdrawal and change in prostate-specific antigen (PSA) when the antiandrogen in question is other than flutamide.

Methods: Presented is a case of a patient in whom the antiandrogen casodex was discontinued after clinical progression despite combined androgen blockade.

Results: A transient decline in serum PSA was observed after casodex withdrawal.

Conclusions: The relationship between antiandrogen withdrawal and a change in PSA may be a general phenomenon, not unique to flutamide.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androgen Antagonists*
  • Anilides*
  • Humans
  • Male
  • Middle Aged
  • Nitriles
  • Prostate-Specific Antigen / blood*
  • Substance Withdrawal Syndrome / blood*
  • Tosyl Compounds


  • Androgen Antagonists
  • Anilides
  • Nitriles
  • Tosyl Compounds
  • bicalutamide
  • Prostate-Specific Antigen