Detection of rotavirus in cerebrospinal fluid and blood of patients with convulsions and gastroenteritis by means of the reverse transcription polymerase chain reaction

Brain Dev. Nov-Dec 1993;15(6):457-9. doi: 10.1016/0387-7604(93)90088-p.

Abstract

Rotavirus RNA was detected in the blood and cerebrospinal fluid from eight Japanese children with convulsions and gastroenteritis in the acute stage by means of the reverse transcription polymerase chain reaction. This may suggest that rotavirus invades the central nervous system through blood vessels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Feces / chemistry
  • Feces / microbiology
  • Female
  • Gastroenteritis / blood
  • Gastroenteritis / cerebrospinal fluid
  • Gastroenteritis / microbiology*
  • Humans
  • Infant
  • Male
  • Polymerase Chain Reaction
  • RNA, Viral / analysis
  • RNA, Viral / blood
  • RNA, Viral / cerebrospinal fluid
  • RNA-Directed DNA Polymerase
  • Rotavirus / isolation & purification*
  • Rotavirus Infections / blood
  • Rotavirus Infections / cerebrospinal fluid
  • Rotavirus Infections / microbiology*
  • Seizures / blood
  • Seizures / cerebrospinal fluid
  • Seizures / microbiology*

Substances

  • RNA, Viral
  • RNA-Directed DNA Polymerase