Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes

Eur J Immunol. 1994 Apr;24(4):1007-9. doi: 10.1002/eji.1830240435.


There is evidence that interleukin -10(IL-10) interferes with the costimulatory properties of antigen-presenting cells and, thereby, inhibits their ability to induce T cell activation. To determine whether this effect might involve modulation of the expression of accessory molecules, we analyzed by flow cytometry the influence of human IL-10 on the basal expression of intercellular adhesion molecule 1 (ICAM-1) as well as on the interferon gamma (IFN-gamma)-induced up-regulation of ICAM-1 and B7 at the surface of human monocytes. IL-10 inhibited both the basal expression and the IFN-gamma-induced ICAM-1 up-regulation. IL-10 also reduced B7 up-regulation on IFN-gamma-stimulated monocytes. The inhibitory effect of IL-10 both on ICAM-1 and B7 expression was shown to be dose dependent. We conclude that the ability of IL-10 to decrease both ICAM-1 and B7 expression on monocytes might contribute to its immunosuppressive properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • B7-1 Antigen / analysis*
  • Cell Adhesion Molecules / analysis*
  • Cells, Cultured
  • HLA-DR Antigens / analysis
  • Humans
  • Intercellular Adhesion Molecule-1
  • Interferon-gamma / pharmacology
  • Interleukin-10 / pharmacology*
  • Monocytes / chemistry
  • Monocytes / drug effects*
  • Recombinant Proteins / pharmacology


  • B7-1 Antigen
  • Cell Adhesion Molecules
  • HLA-DR Antigens
  • Recombinant Proteins
  • Intercellular Adhesion Molecule-1
  • Interleukin-10
  • Interferon-gamma