SCE frequency of herpes simplex virus type I infected cells

Mutat Res. 1994 Apr 1;306(1):81-3. doi: 10.1016/0027-5107(94)90169-4.

Abstract

The effects of herpes simplex virus type I (HSV-I) on SCE frequencies in human lymphocytes in vitro were investigated. SCE frequencies in controls (mean +/- 1SD 5.2 +/- 1.6) and in cells exposed to the virus for 3 and 6 h (mean +/- 1SD 5.3 +/- 1.6 and 5.8 +/- 1.6 respectively) were about the same. However, cells infected for 9 to 24 h showed a significant increase of SCE frequencies (p < 0.05).

MeSH terms

  • Cells, Cultured
  • Herpesvirus 1, Human / pathogenicity*
  • Humans
  • Lymphocytes / ultrastructure
  • Sister Chromatid Exchange*