Cranial metastasis of hepatocellular carcinoma in a female--case report

Neurol Med Chir (Tokyo). 1993 Dec;33(12):839-44. doi: 10.2176/nmc.33.839.


A 78-year-old female presented with swelling and severe pain in the left forehead secondary to a simple head injury received 1 month previously. On admission, neurological examination was normal. Plain skull x-ray films and computed tomography showed an osteolytic and well-defined mass in the left frontal bone. Bone scintigraphy showed high-uptake areas in the right lower ribs and fifth lumbar vertebra. Blood tests showed slight liver dysfunction and a high alpha-fetoprotein level. Abdominal computed tomography showed a huge mass within the liver. Left common carotid angiography disclosed the enlargement of several feeding arteries arising from the external carotid artery with tumor staining. The bone tumor was removed for histological diagnosis and to reduce the localized pain. The histological diagnosis was a cranial metastasis from hepatocellular carcinoma. She died of ruptured varicose veins of the esophagus approximately 8 months after surgery. Surgery for cranial metastasis from hepatic cancer is only indicated when localized pain or hemorrhage threaten the quality of life.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / pathology*
  • Carcinoma, Hepatocellular / ultrastructure
  • Cerebral Angiography
  • Craniocerebral Trauma
  • Female
  • Humans
  • Liver Function Tests
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / ultrastructure
  • Middle Aged
  • Neoplasm Metastasis*
  • Photomicrography
  • Skull Neoplasms / diagnosis
  • Skull Neoplasms / secondary*
  • Skull Neoplasms / surgery
  • Tomography, X-Ray Computed