The acute phase response

Immunol Today. 1994 Feb;15(2):74-80. doi: 10.1016/0167-5699(94)90137-6.


Adult mammals respond to tissue damage by implementing the acute phase response, which comprises a series of specific physiological reactions. This review outlines the principal cellular and molecular mechanisms that control initiation of the tissue response at the site of injury, the recruitment of the systemic defense mechanisms, the acute phase response of the liver and the resolution of the acute phase response.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins / immunology
  • Acute-Phase Reaction / immunology*
  • Animals
  • Humans
  • Liver / immunology


  • Acute-Phase Proteins