One-sided invasion events in homologous recombination at double-strand breaks

Mutat Res. 1994 May;314(3):199-208. doi: 10.1016/0921-8777(94)90065-5.

Abstract

Two classes of homologous recombination mechanism for repair of double-strand breaks (DSBs) have been described in eukaryotes so far. One is conservative and has been explained by the double-strand break repair model (Szostak et al., 1983), whereas the other one is non-conservative and has been explained by the single-strand annealing model (Lin et al., 1984). Here, we will review data supporting the existence of another homologous recombination mechanism for double-strand break repair. We will present the one-sided invasion model that we have proposed to explain this mechanism and discuss its potential implication in various homologous recombination events.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA / metabolism*
  • DNA Repair / physiology*
  • Gene Amplification
  • Models, Genetic*
  • Recombination, Genetic / physiology*

Substances

  • DNA