Predictive value of prostate-specific antigen density for the presence of micrometastatic carcinoma of the prostate

Urology. 1994 May;43(5):645-8. doi: 10.1016/0090-4295(94)90179-1.


Objective: To examine the efficacy of prostate-specific antigen (PSA) density (PSAD; serum PSA/prostate volume) as a predictor of clinical outcome of patients undergoing radical retropubic prostatectomy for clinically confined prostate cancer, and its ability to determine the presence of micrometastatic disease.

Methods: A retrospective analysis of patient outcome as reflected by surgical stage and postoperative PSA was performed with respect to PSAD as determined by preoperative PSA and pathologic prostate gland volume. The findings for 107 consecutive patients who underwent radical prostatectomy are reported.

Results: PSAD at low values was found to be 90 percent accurate in predicting operative success or absence of micrometastatic disease. PSAD at high values was shown to be 70 percent accurate in predicting failure.

Conclusions: PSAD appears to be useful in selecting patients for radical prostatectomy and may be capable of identifying patients with micrometastatic disease.

MeSH terms

  • Biomarkers, Tumor / blood*
  • Humans
  • Male
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Predictive Value of Tests
  • Prostate / pathology
  • Prostate-Specific Antigen / blood*
  • Prostatectomy
  • Prostatic Neoplasms / epidemiology*
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / surgery
  • Retrospective Studies
  • Treatment Outcome


  • Biomarkers, Tumor
  • Prostate-Specific Antigen