Structure of peptides associated with MHC class I molecules

Curr Opin Immunol. 1994 Feb;6(1):13-23. doi: 10.1016/0952-7915(94)90028-0.


Recent progress in understanding the structures of MHC class I molecules and the peptides that they bind has led to a generalized model for peptide binding, and an understanding of allelic specificity. Prediction on the basis of motifs and new techniques for peptide analysis have recently resulted in the identification of several peptides that comprise epitopes for antigen-specific T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigen Presentation
  • Epitopes / immunology
  • Histocompatibility Antigens Class I / immunology*
  • Humans
  • Molecular Sequence Data
  • Peptides / chemistry*
  • Peptides / immunology*


  • Epitopes
  • Histocompatibility Antigens Class I
  • Peptides