Defining rules for the peptide-MHC class II interaction

Curr Opin Immunol. 1994 Feb;6(1):52-6. doi: 10.1016/0952-7915(94)90033-7.


Recent work has begun to clarify the molecular events governing peptide interaction with MHC class II proteins. The requirements for peptide binding to class I and class II molecules seem to be similar. Despite differences in peptide length, anchor residues defining allele-specific peptide motifs can also be found in class II binding peptides. The presence of conserved and allele-specific anchors appears to explain the promiscuity and the specificity of peptide recognition by DR molecules.

Publication types

  • Review

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Epitopes
  • Histocompatibility Antigens Class II / genetics
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Molecular Sequence Data
  • Peptides / chemistry
  • Peptides / immunology*
  • Protein Binding


  • Epitopes
  • Histocompatibility Antigens Class II
  • Peptides