Abstract
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as colorless prisms and the molecular formula was determined as C24H36N4O6S2. This antibiotic reverted the transformed morphology of a Ha-ras transformant to normal, and exhibited prominent antitumor activities against murine and human tumor cell lines both in vitro and in vivo.
MeSH terms
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3T3 Cells / drug effects
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Adenocarcinoma / drug therapy
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Animals
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Anti-Bacterial Agents* / biosynthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / isolation & purification
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Anti-Bacterial Agents* / pharmacology
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Antibiotics, Antineoplastic* / chemistry
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Antibiotics, Antineoplastic* / isolation & purification
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Antibiotics, Antineoplastic* / pharmacology
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Carcinoma / drug therapy
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Cell Line, Transformed
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Chromobacterium / metabolism*
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Depsipeptides*
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Drug Screening Assays, Antitumor
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Female
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Fermentation
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Humans
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Magnetic Resonance Spectroscopy
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Mice, Nude
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Microbial Sensitivity Tests
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Neoplasm Transplantation
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Peptides, Cyclic*
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Tacrolimus / pharmacology
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Tumor Cells, Cultured
Substances
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Anti-Bacterial Agents
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Antibiotics, Antineoplastic
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Depsipeptides
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Peptides, Cyclic
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romidepsin
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Tacrolimus