FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

J Antibiot (Tokyo). 1994 Mar;47(3):301-10. doi: 10.7164/antibiotics.47.301.

Abstract

A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as colorless prisms and the molecular formula was determined as C24H36N4O6S2. This antibiotic reverted the transformed morphology of a Ha-ras transformant to normal, and exhibited prominent antitumor activities against murine and human tumor cell lines both in vitro and in vivo.

MeSH terms

  • 3T3 Cells / drug effects
  • Adenocarcinoma / drug therapy
  • Animals
  • Anti-Bacterial Agents* / biosynthesis
  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / isolation & purification
  • Anti-Bacterial Agents* / pharmacology
  • Antibiotics, Antineoplastic* / chemistry
  • Antibiotics, Antineoplastic* / isolation & purification
  • Antibiotics, Antineoplastic* / pharmacology
  • Carcinoma / drug therapy
  • Cell Line, Transformed
  • Chromobacterium / metabolism*
  • Depsipeptides*
  • Drug Screening Assays, Antitumor
  • Female
  • Fermentation
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mice, Nude
  • Microbial Sensitivity Tests
  • Neoplasm Transplantation
  • Peptides, Cyclic*
  • Tacrolimus / pharmacology
  • Tumor Cells, Cultured

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Depsipeptides
  • Peptides, Cyclic
  • romidepsin
  • Tacrolimus