Platelet aggregation in response to four low molecular weight heparins and the heparinoid ORG 10172 in patients with heparin-induced thrombocytopenia

Br J Haematol. 1994 Feb;86(2):425-6. doi: 10.1111/j.1365-2141.1994.tb04760.x.

Abstract

A simple rapid platelet aggregation test was used to evaluate cross-reactivity of four low molecular weight heparins and the heparinoid ORG 10172 in three patients with heparin-induced thrombocytopenia. The low molecular weight heparins cross-reacted in 11 out of 12 tests. The heparinoid ORG 10172 did not cross-react in any of the patients. One patient was treated with ORG 10172 and thrombocytopenia resolved.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Anticoagulants / pharmacology*
  • Chondroitin Sulfates*
  • Cross Reactions
  • Dermatan Sulfate*
  • Female
  • Glycosaminoglycans / pharmacology*
  • Heparin / adverse effects
  • Heparin, Low-Molecular-Weight / pharmacology*
  • Heparinoids / pharmacology
  • Heparitin Sulfate*
  • Humans
  • Platelet Aggregation / drug effects*
  • Thrombocytopenia / chemically induced*

Substances

  • Anticoagulants
  • Glycosaminoglycans
  • Heparin, Low-Molecular-Weight
  • Heparinoids
  • Dermatan Sulfate
  • Heparin
  • Chondroitin Sulfates
  • Heparitin Sulfate
  • danaparoid