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Review
, 101 Suppl 6 (Suppl 6), 39-44

Alpha 2u-globulin Nephropathy: Review of the Cellular and Molecular Mechanisms Involved and Their Implications for Human Risk Assessment

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Review

Alpha 2u-globulin Nephropathy: Review of the Cellular and Molecular Mechanisms Involved and Their Implications for Human Risk Assessment

J A Swenberg. Environ Health Perspect.

Abstract

This paper reviews what is known about the induction of alpha 2u-globulin nephropathy and carcinogenesis. This unique male-rat-specific disease is associated with exposure to an ever-increasing number of chemicals. The processes leading to nephropathy and renal cancer are among the best-understood mechanisms for nongenotoxic chemicals and strongly support that it is a male-rat-specific process that is not relevant for human risk assessment. Nevertheless, the data available for individual chemicals vary greatly. This necessitates a case-by-case analysis of the available data when determining the relevance for humans of this chemically induced renal disease in male rats.

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