Distinctive developmental origins and specificities of murine CD5+ B cells

Immunol Rev. 1994 Feb;137:91-118. doi: 10.1111/j.1600-065x.1994.tb00660.x.


CD5+ B cells constitute a small fraction of cells in the spleen of adult mice that exhibit numerous features serving to distinguish them from the bulk of IgD++CD5- "conventional" B cells. In this review we focus on two major questions relating to this population: 1) the relationship of CD5+ B cells to other B cells; and 2) the distinctive enrichment of particular autoreactive specificities in this subset. The nature of their origins is clarified by a thorough analysis of intermediate stages of early B-cell development in both fetal and adult tissues. The reactivity to bromelain-treated mouse red blood cells serves as a prototype system for the investigation of biased specificities in CD5+ B cells. These lines of investigation lead us to propose that CD5+ B cells in the adult are the remnant of a distinct fetal B-cell differentiation pathway wherein selection of cells from this fetal/neonatal population into the adult long-lived pool results in the over-expression of certain germline-encoded autoreactivities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD / immunology*
  • B-Lymphocytes / physiology*
  • Base Sequence
  • CD5 Antigens
  • Cell Differentiation
  • Epitopes / immunology*
  • Gene Rearrangement, B-Lymphocyte / genetics
  • Gene Rearrangement, B-Lymphocyte / immunology
  • Genes, Immunoglobulin / immunology
  • Immunoglobulin D / immunology
  • Molecular Sequence Data


  • Antigens, CD
  • CD5 Antigens
  • Epitopes
  • Immunoglobulin D