Abstract
We measured soluble CD14 (sCD14), plasma endotoxin, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), IL-6, and interferon-gamma (IFN-gamma) in patients with multiple organ failure (MOF). The sCD14 level was significantly higher in septic patients with MOF than that in those without MOF and also higher in non-septic trauma patients with MOF than that in those without MOF. In the septic group with MOF, the sCD14 level correlated significantly with the TNF-alpha level but not the plasma endotoxin, IL-1 beta, IL-6, or IFN-gamma level. These results suggest that the sCD14 level reflects the degree of pathophysiology and that TNF-alpha is involved in stimulating sCD14 production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antigens, CD / blood*
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Antigens, Differentiation, Myelomonocytic / blood*
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Bacteremia / complications
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Bacteremia / metabolism*
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Endotoxins / blood*
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Interferon-gamma / blood
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Interleukins / blood
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Lipopolysaccharide Receptors
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Male
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Middle Aged
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Multiple Organ Failure / blood*
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Multiple Organ Failure / complications
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Severity of Illness Index
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Tumor Necrosis Factor-alpha / metabolism
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Wounds and Injuries / blood*
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Wounds and Injuries / complications
Substances
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Antigens, CD
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Antigens, Differentiation, Myelomonocytic
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Endotoxins
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Interleukins
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Lipopolysaccharide Receptors
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Tumor Necrosis Factor-alpha
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Interferon-gamma