Soluble CD14 (sCD14) levels in patients with multiple organ failure (MOF)

Res Commun Chem Pathol Pharmacol. 1994 Apr;84(1):17-25.

Abstract

We measured soluble CD14 (sCD14), plasma endotoxin, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), IL-6, and interferon-gamma (IFN-gamma) in patients with multiple organ failure (MOF). The sCD14 level was significantly higher in septic patients with MOF than that in those without MOF and also higher in non-septic trauma patients with MOF than that in those without MOF. In the septic group with MOF, the sCD14 level correlated significantly with the TNF-alpha level but not the plasma endotoxin, IL-1 beta, IL-6, or IFN-gamma level. These results suggest that the sCD14 level reflects the degree of pathophysiology and that TNF-alpha is involved in stimulating sCD14 production.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antigens, CD / blood*
  • Antigens, Differentiation, Myelomonocytic / blood*
  • Bacteremia / complications
  • Bacteremia / metabolism*
  • Endotoxins / blood*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interferon-gamma / blood
  • Interleukins / blood
  • Lipopolysaccharide Receptors
  • Male
  • Middle Aged
  • Multiple Organ Failure / blood*
  • Multiple Organ Failure / complications
  • Severity of Illness Index
  • Tumor Necrosis Factor-alpha / metabolism
  • Wounds and Injuries / blood*
  • Wounds and Injuries / complications

Substances

  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • Endotoxins
  • Interleukins
  • Lipopolysaccharide Receptors
  • Tumor Necrosis Factor-alpha
  • Interferon-gamma