Chromosome abnormalities in benign prostatic hyperplasia

Genes Chromosomes Cancer. 1994 Apr;9(4):227-33. doi: 10.1002/gcc.2870090402.


We combined conventional cytogenetic analysis and fluorescence in situ hybridization of short-term cultures of 28 samples from benign prostatic hyperplasia. Loss of the Y chromosome was the most common chromosome change, followed by trisomy 7. Trisomy 7, however, may be unrelated to the origin of benign prostate hyperplasia, in which the only and not very specific change seems to be the loss of the Y chromosome.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Cells, Cultured
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 7
  • Humans
  • In Situ Hybridization, Fluorescence
  • Male
  • Middle Aged
  • Prostatic Hyperplasia / genetics*
  • Rabbits
  • Trisomy
  • Y Chromosome*