Epitope discovery using peptide libraries displayed on phage

Trends Biotechnol. 1994 Jul;12(7):262-7. doi: 10.1016/0167-7799(94)90137-6.


Peptides displayed on phage, which mimic continuous and discontinuous epitopes, can be selected using purified antibodies or preparations of polyclonal serum. This review describes recent advances in this field, discusses the application of phage-display technology to the diagnosis of human diseases, and presents new ideas for the preparation of vaccines directed against specific epitopes on a pathogen.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacteriophages / genetics*
  • Epitopes / analysis*
  • Epitopes / genetics
  • Gene Library
  • Humans
  • Molecular Sequence Data
  • Recombinant Proteins / analysis
  • Recombinant Proteins / genetics
  • Recombinant Proteins / immunology
  • T-Lymphocytes / immunology
  • Vaccines / immunology


  • Epitopes
  • Recombinant Proteins
  • Vaccines