Localization of striatal and nigral tachykinin receptors in the rat

Brain Res. 1994 May 16;646(1):13-8. doi: 10.1016/0006-8993(94)90052-3.

Abstract

The effects of lesioning mesostriatal dopamine projections or striatal neurons on tachykinin binding in the basal ganglia were assessed in the rat. 6-Hydroxydopamine lesions of the medial forebrain bundle destroyed striatal dopamine terminals as assessed by [3H]mazindol autoradiography, but did not significantly affect the binding of NK-1 ([3H][Sar9,Met(O2)11]substance P) or NK-3 ([3H]senktide) tachykinin ligands in the striatum. 6-Hydroxydopamine lesions significantly reduced NK-3 binding in the substantia nigra pars compacta, but not the ventral tegmental area. In contrast, striatal quinolinic acid lesions reduced both NK-1 and NK-3 binding in the striatum, but failed to affect NK-3 binding in the substantia nigra. These findings suggest that both NK-1 and NK-3 receptors within the striatum are predominantly post-synaptic with respect to dopamine neurons, whereas nigral NK-3 receptors are located on dopaminergic neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoradiography
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism*
  • Male
  • Mazindol / metabolism
  • Medial Forebrain Bundle / drug effects
  • Oxidopamine / pharmacology
  • Peptide Fragments / metabolism
  • Quinolinic Acid / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Tachykinin / metabolism*
  • Substance P / analogs & derivatives
  • Substance P / metabolism
  • Substantia Nigra / metabolism*
  • Tissue Distribution

Substances

  • Peptide Fragments
  • Receptors, Tachykinin
  • senktide
  • Substance P
  • Oxidopamine
  • Mazindol
  • Quinolinic Acid